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  • Celina McBeath
  • bloodvitals-wearable6012
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  • #19

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Opened Aug 17, 2025 by Celina McBeath@celinamcbeath0
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A Blood Flow Probe (PS-Series Probes


The administration of epinephrine in the administration of non-traumatic cardiac arrest stays recommended regardless of controversial results on neurologic consequence. The usage of resuscitative endovascular balloon occlusion of the aorta (REBOA) could be an fascinating alternative. The aim of this research was to match the results of those 2 methods on return of spontaneous circulation (ROSC) and cerebral hemodynamics throughout cardiopulmonary resuscitation (CPR) in a swine model of non-traumatic cardiac arrest. Anesthetized pigs have been instrumented and submitted to ventricular fibrillation. After 4 min of no-circulation and 18 min of fundamental life assist (BLS) using a mechanical CPR gadget, animals were randomly submitted to either REBOA or epinephrine administration before defibrillation attempts. Six animals had been included in every experimental group (Epinephrine or REBOA). Hemodynamic parameters had been similar in both teams during BLS, i.e., before randomization. After epinephrine administration or REBOA, mean arterial stress, coronary and cerebral perfusion pressures equally elevated in each teams.


40%, respectively). ROSC was obtained in 5 animals in each teams. After resuscitation, CBF remained decrease in the epinephrine group as in comparison with REBOA, nevertheless it didn't achieve statistical significance. During CPR, REBOA is as environment friendly as epinephrine to facilitate ROSC. Unlike epinephrine, REBOA transitorily increases cerebral blood move and could keep away from its cerebral detrimental effects throughout CPR. These experimental findings suggest that using REBOA may very well be useful within the therapy of non-traumatic cardiac arrest. Although using epinephrine is beneficial by worldwide tips in the therapy of cardiac arrest (CA), the useful effects of epinephrine are questioned during superior life assist. Experimental data provide some answers to these ambivalent results of epinephrine (i.e., favorable cardiovascular vs unfavorable neurologic results). With this in mind, other strategies are thought of to keep away from the administration of epinephrine throughout CPR. Accordingly, the objective of this research was to find out whether the effect of REBOA during CPR on cardiac afterload may very well be used instead for epinephrine administration in non-traumatic CA, to acquire ROSC while avoiding deleterious results of epinephrine on cerebral microcirculation.


Ventilation parameters have been adjusted to take care of normocapnia. They have been then instrumented with fluid-filled catheters positioned into the descending aorta and proper atrium by means of two sheaths (9Fr) inserted into the left femoral artery and vein, respectively, with the intention to invasively monitor mean arterial pressure (MAP) and right atrial stress. Coronary perfusion strain (CoPP) was then calculated as the difference between MAP and mean right atrial stress. During CPR, measures were made at end-decompression. A blood movement probe (PS-Series Probes, Transonic, BloodVitals SPO2 NY, BloodVitals SPO2 USA) was surgically placed around the carotid artery to monitor carotid blood move (CBF). A stress sensing catheter (Millar®, SPR-524, Houston, TX, BloodVitals wearable USA) was inserted after craniotomy to monitor intracranial pressure (ICP). CePP/CBF). Electrocardiogram (ECG) and end-tidal CO2 have been repeatedly monitored. So as to observe cerebral regional oxygen saturation, a Near-infrared spectroscopy (NIRS) electrode was attached to the pig’s scalp over the suitable hemisphere (INVOS™ 5100C Cerebral/Somatic Oximeter, Medtronic®). After surgical preparation and stabilization, ventilation was interrupted, and ventricular fibrillation (VF) was induced through the use of a pacemaker catheter introduced into the precise ventricle by the venous femoral sheath.


VF was left untreated for four min, after which typical CPR was initiated using an automated gadget (LUCAS III, Stryker Medical®, Kalamazoo, MI, USA), at the rate of 100 compressions/min. 0 cmH2O). As illustrated in Fig. 1, animals were randomized to one of many 2 therapy teams, i.e., REBOA or Epinephrine (EPI). In REBOA, the REBOA Catheter (ER-REBOA, Prytime Medical®, Boerne, BloodVitals SPO2 TX, USA) was inserted into the arterial femoral sheath and left deflated until needed. The balloon was positioned in zone I (i.e., within the thoracic descending aorta) by utilizing anatomical landmarks. Correct placement of the REBOA was checked by publish-mortem examination. After 18 min of CPR, the balloon was inflated and remained so till ROSC was obtained. In EPI, animals were given a 0.5 mg epinephrine intravenous bolus after 18 min of CPR, and then each 4 min if vital, till ROSC. Defibrillation makes an attempt started after 20 min of CPR, i.e., 2 min after epinephrine administration or balloon occlusion. After ROSC, BloodVitals SPO2 mechanical chest compressions were interrupted, and initial mechanical ventilation parameters were resumed.

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Reference: celinamcbeath0/bloodvitals-wearable6012#19